Factors associated with metabolic syndrome in patients with systemic lupus erythematosus from Puerto Rico
Identifieur interne : 001A02 ( Main/Exploration ); précédent : 001A01; suivant : 001A03Factors associated with metabolic syndrome in patients with systemic lupus erythematosus from Puerto Rico
Auteurs : Am Negr N [Porto Rico] ; Mj Molina [Porto Rico] ; Am Mayor [Porto Rico] ; Ve Rodríguez [Porto Rico] ; Lm Vilá [Porto Rico]Source :
- Lupus [ 0961-2033 ] ; 2008-04.
English descriptors
- Teeft :
- American college, American heart association, Arthritis rheum, Blood institute, Body mass index, Cardiovascular, Cardiovascular disease, Classification criteria, Clinical manifestations, Coronary artery disease, Damage accrual, Diabetes mellitus, Disease activity, Disease damage, Disease duration, Drug treatment, Erythematosus, Erythrocyte sedimentation rate, Fasting blood glucose, Government health insurance, Individual components, Insulin resistance, Lupus, Lupus patients, Metabolic, Metabolic syndrome, Multivariable analyses, National heart, Prednisone, Present study, Puerto rico, Rheum, Rheumatol, Rheumatology, Rheumatology classification criteria, Rheumatology damage index, Sciences campus, Serologic features, Socioeconomic status, Standard deviation, Study visit, Syndrome, Systemic, Systemic lupus, Systemic lupus erythematosus, Thrombocytopenia, Tumor necrosis factor.
Abstract
The aim of this study was to determine the factors associated with metabolic syndrome in patients with systemic lupus erythematosus from Puerto Rico. A total of 204 patients with systemic lupus erythematosus (per the American College of Rheumatology classification criteria) were evaluated. Metabolic syndrome was assessed using the American Heart Association and the National Heart, Lung, and Blood Institute classification. Socioeconomic–demographic parameters, health-related behaviours, clinical manifestations, autoantibodies, pharmacological treatments, disease activity (per the Systemic Lupus Activity Measure—Revised), and damage accrual (per the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index) were determined at study visit. Factors associated with metabolic syndrome were examined by univariable analyses and multivariable logistic regression models. A total of 196 (96.2%) were women. The mean age at study visit was 43.6 ± 13.0 years, and the mean disease duration was 8.7 ± 7.7 years. Seventy-eight patients (38.2%) had metabolic syndrome. In the multivariable analysis, age (odds ratio [OR] = 1.05; 95% confidence interval [CI] 1.02–1.09), government health insurance (OR = 2.06; 95% CI 1.07–4.22), exercise (OR = 0.33; 95% CI 0.14–0.92), thrombocytopenia (OR = 4.19; 95% CI 1.54–11.37), erythrocyte sedimentation rate (OR = 1.64; 95% CI 1.03–2.63), disease activity (OR = 1.14; 95% CI 1.00–1.30), and prednisone >10 mg/day (OR = 3.69; 95% CI 1.22–11.11) were associated with metabolic syndrome. In conclusion, older age, low socioeconomic status, lack of exercise, thrombocytopenia, increased erythrocyte sedimentation rate , higher disease activity, and prednisone >10 mg/day were independently associated with metabolic syndrome in patients with systemic lupus erythematosus from Puerto Rico.
Url:
DOI: 10.1177/0961203307086645
Affiliations:
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criteria</term><term>Clinical manifestations</term><term>Coronary artery disease</term><term>Damage accrual</term><term>Diabetes mellitus</term><term>Disease activity</term><term>Disease damage</term><term>Disease duration</term><term>Drug treatment</term><term>Erythematosus</term><term>Erythrocyte sedimentation rate</term><term>Fasting blood glucose</term><term>Government health insurance</term><term>Individual components</term><term>Insulin resistance</term><term>Lupus</term><term>Lupus patients</term><term>Metabolic</term><term>Metabolic syndrome</term><term>Multivariable analyses</term><term>National heart</term><term>Prednisone</term><term>Present study</term><term>Puerto rico</term><term>Rheum</term><term>Rheumatol</term><term>Rheumatology</term><term>Rheumatology classification criteria</term><term>Rheumatology damage index</term><term>Sciences campus</term><term>Serologic features</term><term>Socioeconomic status</term><term>Standard deviation</term><term>Study visit</term><term>Syndrome</term><term>Systemic</term><term>Systemic lupus</term><term>Systemic lupus erythematosus</term><term>Thrombocytopenia</term><term>Tumor necrosis factor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to determine the factors associated with metabolic syndrome in patients with systemic lupus erythematosus from Puerto Rico. A total of 204 patients with systemic lupus erythematosus (per the American College of Rheumatology classification criteria) were evaluated. Metabolic syndrome was assessed using the American Heart Association and the National Heart, Lung, and Blood Institute classification. Socioeconomic–demographic parameters, health-related behaviours, clinical manifestations, autoantibodies, pharmacological treatments, disease activity (per the Systemic Lupus Activity Measure—Revised), and damage accrual (per the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index) were determined at study visit. Factors associated with metabolic syndrome were examined by univariable analyses and multivariable logistic regression models. A total of 196 (96.2%) were women. The mean age at study visit was 43.6 ± 13.0 years, and the mean disease duration was 8.7 ± 7.7 years. Seventy-eight patients (38.2%) had metabolic syndrome. In the multivariable analysis, age (odds ratio [OR] = 1.05; 95% confidence interval [CI] 1.02–1.09), government health insurance (OR = 2.06; 95% CI 1.07–4.22), exercise (OR = 0.33; 95% CI 0.14–0.92), thrombocytopenia (OR = 4.19; 95% CI 1.54–11.37), erythrocyte sedimentation rate (OR = 1.64; 95% CI 1.03–2.63), disease activity (OR = 1.14; 95% CI 1.00–1.30), and prednisone >10 mg/day (OR = 3.69; 95% CI 1.22–11.11) were associated with metabolic syndrome. In conclusion, older age, low socioeconomic status, lack of exercise, thrombocytopenia, increased erythrocyte sedimentation rate , higher disease activity, and prednisone >10 mg/day were independently associated with metabolic syndrome in patients with systemic lupus erythematosus from Puerto Rico.</div></front></TEI><affiliations><list><country><li>Porto Rico</li></country></list><tree><country name="Porto Rico"><noRegion><name sortKey="Negr N, Am" sort="Negr N, Am" uniqKey="Negr N A" first="Am" last="Negr N">Am Negr N</name></noRegion><name sortKey="Mayor, Am" sort="Mayor, Am" uniqKey="Mayor A" first="Am" last="Mayor">Am Mayor</name><name sortKey="Molina, Mj" sort="Molina, Mj" uniqKey="Molina M" first="Mj" last="Molina">Mj Molina</name><name sortKey="Rodriguez, Ve" sort="Rodriguez, Ve" uniqKey="Rodriguez V" first="Ve" last="Rodríguez">Ve Rodríguez</name><name sortKey="Vila, Lm" sort="Vila, Lm" uniqKey="Vila L" first="Lm" last="Vilá">Lm Vilá</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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